TyG指数与肥胖指标和冠心病之间的关联:一项队列研究
Ying Miao1,2,3,4,5,6, Yu Wang7, Qin Wan8,9,10,11,12,13
1Department of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou, China.
三甘油糖 (TyG) 指数与腰围 (TyG-WC) 等肥胖指标相结合,可以预测老年人冠心病 (CHD) 风险. TyG-WC显示,对新发性冠状动脉疾病具有显著的预测价值.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 流行病学 流行病学
背景情况:
- 三甘油糖 (TyG) 指数的预测价值及其与中年和老年人群中冠心病 (CHD) 风险的肥胖指标的组合尚未完全理解.
- 评估这些标志物对于早期风险分层和预防策略至关重要.
研究的目的:
- 评估TyG指数及其与肥胖指标 (TyG-WC,TyG-WtHR,TyG-BMI,TyG-WHR) 组合的预测能力,用于新发性心脏病的10年发病率.
- 为了确定预测中年和老年人群中CHD最有效的指标.
主要方法:
- 一项队列研究涉及8647名来自中国心脏代谢疾病和癌症队列 (4C) 研究的参与者.
- 参与者根据TyG,TyG-WC,TyG-WtHR,TyG-BMI和TyG-WHR分为四分之一.
- 新发性心脏病发病率在10年内进行了监测,统计分析包括考克斯比例危险回归和ROC曲线分析.
主要成果:
- 在所有五个指标的四分位数中观察到新发性心血管疾病发病率的统计学上显著差异 (P < 0.001).
- 新发性心血管疾病的风险随着TyG和其肥胖组合的四分位数较高而逐渐增加,在调整了混因素后.
- 与TyG,TyG-BMI和TyG-WHR相比,TyG-WC (AUC 0.608) 和TyG-WtHR (AUC 0.608) 在新发性心脏病的预测价值更高.
结论:
- 泰格指数及其与肥胖指标的组合与中年和老年人中新发性心血管疾病发病率相关.
- TyG-WC成为老年人冠心病发生的重要预测因素,突出其临床实用性.
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