社会劣势加快了老龄化进程
Mika Kivimäki1,2, Jaana Pentti3,4, Philipp Frank5,3
1Brain Sciences, University College London, London, UK. m.kivimaki@ucl.ac.uk.
Nature medicine
|March 15, 2025
概括
社会劣势加快了生物衰老,增加了许多与年龄有关的疾病的风险. 这通过特定的与年龄相关的蛋白质和炎症途径发生,突出显示了社会因素和健康结果之间的生物联系.
科学领域:
- 老年学是一门学科.
- 社会流行病学 社会流行病学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 社会劣势是已知的健康风险因素,但其对衰老过程的影响尚不清楚.
- 研究社会劣势与生物衰老之间的联系对于理解健康差异至关重要.
研究的目的:
- 检查社会劣势与与年龄相关的血蛋白之间的关联.
- 确定社会劣势是否与与年龄有关的疾病风险增加有关.
主要方法:
- 使用多队列方法分析血蛋白质组数据.
- 研究了社会劣势,特定蛋白质和疾病风险之间的关联.
主要成果:
- 蛋白质组特征表明,在社会不利的人群中,免疫衰老加速.
- 确定了14种特定的与年龄相关的蛋白质,这些蛋白质与整个生命周期的社会劣势有关.
- 社会劣势与66种与年龄相关的疾病的风险增加有关,这些疾病的部分介导是由这些蛋白质.
- 调节NF-κB24通路和互白素-8的升级是一个关键发现.
结论:
- 在一生中处于社会不利地位可能会加速生物衰老.
- 这种加速的衰老过程涉及特定的蛋白质和炎症通路,可以增加与年龄有关的疾病的风险.
- 这些发现支持一种将社会分层与健康结果联系起来的生物机制.
相关概念视频
Aging
34
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
34
The Effect of Aging on Tissues
2.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.0K
Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
Stereotypes, Prejudice, and Discrimination
89.8K
Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who...
89.8K
Erikson's Theory on Socioemotional Development during Adulthood
46
Erik Erikson's theory of psychosocial development outlines a series of stages through which individuals progress across the lifespan. Each stage involves a psychosocial conflict that significantly influences personal growth and well-being. Three key stages — intimacy versus isolation, generativity versus stagnation, and integrity versus despair — highlight the developmental challenges faced in adulthood.
Intimacy Versus Isolation in Early Adulthood
Individuals in early...
Intimacy Versus Isolation in Early Adulthood
Individuals in early...
46
Cognitive Development During Adulthood
42
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
42


