母亲的高脂肪饮食会通过表观遗传记忆加剧子女的动脉样硬化发展
Kan Li1,2, Weiqi Qian1, Fangni Zhang1
1State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.
Nature cardiovascular research
|March 15, 2025
概括
母亲接触西方饮食会在胎儿内皮细胞中产生持久的表观遗传记忆,增加后代.
科学领域:
- 心血管生物学 心血管生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 健康和疾病的发育起源
背景情况:
- 母亲的西方饮食 (WD) 摄入增加了子女患动脉样硬化风险.
- 由母亲风险因素驱动的内皮细胞 (EC) 功能障碍有助于这种易感性.
- 关联母亲饮食与后代EC功能障碍的精确分子机制尚未完全理解.
研究的目的:
- 阐明母体WD诱导长期EC功能障碍并加速成年后代动脉样硬化的表观遗传机制.
- 研究激活蛋白-1 (AP-1) 和染色质重塑在调解这种效应中的作用.
主要方法:
- 使用母乳WD暴露的小鼠模型.
- 从成年后代分析了主动脉EC,以检测炎症标志物和表观遗传修饰.
- 研究了27-胆固醇在表观遗传记忆形成中的作用.
- 评估了抑制AP-1结合对EC炎症和动脉形成的影响.
主要成果:
- 母亲WD通过AP-1和染色体动力学诱导子女大动脉EC中的表观遗传记忆.
- 27-基胆固醇放大了炎症基因表达和AP-1/p300和H3K27ac的丰富.
- 抑制AP-1结合减少了人类EC和后代动脉动脉发生的炎症.
结论:
- 母亲WD通过在EC中建立AP-1-驱动的表观遗传记忆来加剧后代动脉样硬化.
- 这种表观遗传记忆增加了染色质对炎症基因的可访问性,促进了EC功能障碍.
- 针对AP-1提供了一种潜在的治疗策略,以减轻饮食引起的心血管风险.
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