尼日利亚白银纳米复合物的使用作为替代疗法,用于抗 thioacetamide 毒性
Fatma M El-Demerdash1, Ansam B Al Mhanna2, Raghda A El-Sayed2
1Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, 21526, Egypt. eldemerdashf@alexu.edu.eg.
Genes & nutrition
|March 15, 2025
概括
与其水性提取物 (NSAE) 相比,Nigella sativa银纳米复合物 (NS-Ag-NC) 对乙 (TAA) 毒性提供了优越的脏保护. 这两种形式都能恢复抗氧化剂平衡并减少炎症,而NS-Ag-NC显示出更强大的脏保护作用.
科学领域:
- 草药是一种草药.
- 纳米技术 纳米技术
- 毒理学 毒理学 毒理学
- 脏生理学 脏生理学
背景情况:
- 黑子 (Nigella sativa) 是一种传统的草药药,具有记录的治疗特性.
- 乙胺 (TAA) 是一种已知的毒剂,用于在实验模型中诱导损伤.
- 药用植物的银纳米复合物正在探索,以提高治疗效果.
研究的目的:
- 在大鼠中研究尼日利亚草水性提取物 (NSAE) 和其银纳米复合物 (NS-Ag-NC) 对TAA诱导的损伤的脏保护作用.
- 为了比较NS-Ag-NC与NSAE在减轻TAA毒性的疗效.
- 阐明涉及抗氧化和抗炎途径的潜在机制.
主要方法:
- 雄性Wistar大鼠被分为六个组:对照组,NSAE,NS-Ag-NC,TAA,TAA + NSAE,以及TAA + NS-Ag-NC.
- 评估了功能,氧化应激标志物 (TBARS,H2O2),抗氧化酶活性,脂质特征,血液学参数和基因表达 (TNF-α,IL-1β,NF-κβ,COX-2).
- 对NSAE进行GC-MS分析,以确定其植物化学成分.
主要成果:
- TAA的使用显著增加了氧化应激,功能受损,脂质和血液状况变化,以及高调的促炎基因.
- 无论是NSAE还是NS-Ag-NC治疗都减轻了TAA诱导的毒性,恢复了抗氧化剂状态和功能.
- 与NSAE相比,NS-Ag-NC表现出更明显的脏保护作用,有效调节氧化剂/抗氧化剂平衡和炎症反应.
结论:
- 尼日利亚白银纳米复合物 (NS-Ag-NC) 具有显著的脏保护性,可以防止TAA诱导的脏损伤.
- 在减轻氧化应激和炎症方面,NS-Ag-NC比Nigella sativa水性提取物 (NSAE) 更有效.
- 这些发现突显了NS-Ag-NC作为保护治疗剂的潜力.
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