家庭水的硬度,遗传风险和心血管疾病的不同表型
Feng Tian1, Genfeng Yu2, Mengyuan Yang1
1Health Management Division, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China.
Environmental health : a global access science source
|March 15, 2025
概括
饮用中等硬度水 (121-180 mg/L) 与患心房动 (AF) 和其他心血管疾病的风险较低有关. 更软或更硬的水可能会增加风险,显示出U形的关联.
科学领域:
- 心血管流行病学心血管流行病学
- 环境健康 环境健康
- 遗传学 是一个遗传学.
背景情况:
- 家庭用水的硬度是一个可修改的环境因素.
- 它与心血管疾病的关联,包括心房动 (AF),心力衰竭 (HF),冠心病 (CHD) 和中风,需要进一步调查.
- 遗传倾向可能会影响个体对心血管风险的敏感性.
研究的目的:
- 检查家用水硬度与AF发生率之间的关系.
- 调查水的硬度和AF的遗传易感性之间的潜在相互作用.
- 评估与发生的HF,CHD和中风的关联.
主要方法:
- 利用英国生物库前性队列研究 (n=447,950用于AF,n=423,946用于其他结果).
- 通过CaCO3度评估水的硬度,并计算AF的多基因风险得分.
- 采用了Cox的比例危险回归和受限立方线分析.
主要成果:
- 在水硬度和事件AF之间观察到U形的关联.
- 121-180毫克/升的水硬度与与≤60毫克/升相比降低了17%的AF风险有关.
- 这种硬度水平也显示了发生HF,CHD和中风的风险降低,没有显著的基因环境相互作用.
结论:
- 家庭用水的硬度与发生的AF呈现出U形的关联.
- 适度硬的水 (121-180 mg/L) 似乎对心血管健康最有益,降低了AF,HF,CHD和中风的风险.
- 水的硬度是影响心血管疾病风险的重要环境因素,独立于遗传易感性.
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