低卡路里饮食和中国人2型糖尿病的缓解:表型变化和个体变化
Zhenxiu Liu1, Nannan Feng2, Sujing Wang2
1Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200025, China.
Nutrition journal
|March 15, 2025
概括
低热量饮食在中国成年人中实现了2型糖尿病 (T2D) 缓解,与其他人口相比. 配方饮食和真实食物饮食都同样有效,但需要注意个体的变化.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 营养科学 营养科学
背景情况:
- 中国人群表现出明显的2型糖尿病 (T2D) 和肥胖现象.
- 关于低卡路里饮食干预T2D缓解的先前研究没有专注于中国人.
- 这项研究通过调查使用低热量饮食的中国成年人T2D缓解来弥补这一差距.
研究的目的:
- 评估低卡路里配方饮食 (LCFD) 和低卡路里真实食品饮食 (LCRFD) 在实现中国成年人T2D缓解方面的有效性.
- 确定影响个人对T2D缓解干预反应的因素.
- 在这个人群中比较LCFD与LCRFD的有效性.
主要方法:
- 一个为期6个月的干预,三个月的强化减肥阶段 (815-835 kcal/d),然后是三个月的体重维持阶段.
- 患有T2D (BMI 24-45 kg/m2,HbA1c 6.5-12.0%) 的参与者停止服用抗糖尿病药物.
- 对LCFD (n=21) 或LCRFD (n=20) 进行随机分配.
主要成果:
- 56.1%的参与者在6个月后实现了T2D缓解.
- 肝脏和胰腺脂肪的显著减少,以及胰岛素敏感性和心脏代谢风险因素的改善.
- 在LCFD和LCRFD组之间的结果没有显著差异;非响应者更有可能是糖尿病持续时间较长,血糖控制较差的女性.
结论:
- 低热量饮食干预可以在中国人群中实现与其他种族观察到的可比的T2D缓解率和体重减轻.
- 在促进T2D缓解方面,LCFD和LCRFD都表现出类似的有效性.
- 缓解的个体变化存在,受性别,脂肪量,糖尿病持续时间和基线血糖控制等因素的影响.
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