在马来西亚吉隆坡的固体器官癌症患者中与血栓形成相关的因素
Lailatulema Abbas1,2, Ibtisam Muhamad Nor3, Fuad Ismail4
1Clinical Haematology Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur, 56000, Malaysia.
Thrombosis journal
|March 15, 2025
概括
癌症相关血栓形成 (CAT) 影响马来西亚固体器官癌症患者,在治疗期间发生率上升. 风险因素包括表现不佳的状态,肥胖和特定的化疗,突出了像Khorana得分这样的工具对风险分层的需求.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 固体器官癌症患者面临癌症相关血栓形成 (CAT) 的风险增加.
- 有限的数据存在于各种种族群体的CAT风险因素,包括马来西亚人.
- 这项研究调查了多民族马来西亚队列中的CAT发病率和风险因素.
研究的目的:
- 为了确定马来西亚固体器官癌症患者中CAT的发病率.
- 确定患者特异性,癌症相关和治疗相关的CAT风险因素.
- 评估风险分层工具的实用性,例如Khorana评分.
主要方法:
- 从2022年5月到2023年8月,对250名固体器官癌症患者 (≥18岁) 的观察队列研究.
- 数据收集包括人口统计,临床特征,癌症治疗和血栓事件.
- 使用多变量后勤回归和ROC分析来识别独立的风险因素,并评估Khorana评分的预测值.
主要成果:
- 在基线时,CAT患病率为4.8%,在随访期间为12%.
- 低绩效状态和肥胖与基线CAT相关.
- 在随访期间,第四阶段的疾病,放射治疗,基化疗和抗代谢物与CAT有关. 科拉纳分数 (KRS) 显著预测了CAT (AUC=0.701).
结论:
- 马来西亚固体器官癌症患者的CAT发病率与全球数据相比较.
- 临床特征预测基线CAT,而疾病和治疗因素预测后续CAT.
- 针对性血栓预防和风险分层工具,如Khorana得分,对于高风险患者的CAT管理至关重要.
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