用于分类患有骨关节炎的患者的术语和定义:范围审查
Gabriel Gijon-Nogueron1, Peter Balint2, Anastas Batalov3
1Department Nursing and Podiatry, University of Malaga, Malaga, Spain. gagijon@uma.es.
BMC rheumatology
|March 15, 2025
概括
本综述综合了临床骨关节炎 (OA) 表型,确定了炎症和代谢等八个类别. 标准化开放式学习术语和使用基于表型的方法可以改善个性化治疗和研究.
科学领域:
- 类风湿病学 类风湿病学
- 遗传学 遗传学是一种遗传学.
- 代谢学 代谢学 代谢学
- 生物力学 生物力学
背景情况:
- 骨关节炎 (OA) 是一种致残的疾病,由于复杂的遗传,代谢,生物机械和环境因素,它具有多种不同的临床表现.
- 对OA临床表型的不一致的术语阻碍了沟通和研究翻译.
- 关于OA临床表型,术语和定义的现有文献需要综合来为未来的研究提供信息.
研究的目的:
- 综合现有的临床骨关节炎 (OA) 现象型,术语和定义的文献.
- 为推进OA研究和临床实践提出一个研究议程.
- 为了解决围绕OA临床表型的不一致术语.
主要方法:
- 根据PRISMA-ScR指南进行范围审查.
- 在MEDLINE,SCOPUS和EBSCO中进行的搜索为2010-2023年关于成人OA临床表型的出版物提供了主机.
- 两位独立审查员在选196项已识别的研究后绘制和分析了数据.
主要成果:
- 包括50项研究,分类了8种临床OA表型:炎症性,生物机械性,代谢性,疼痛敏感性,最小关节疾病,心理驱动,更年期和严重放射性.
- 大多数研究集中在膝关节OA上,对手,中脚和部OA表型的探索有限.
- 基于表型的管理策略显示出改善治疗结果和指导研究的潜力.
结论:
- 标准化术语和利用基于表型的框架对于个性化的开放式治疗和研究至关重要.
- 未来的努力应集中在验证标准,开发诊断工具和调查研究不足的OA表型上.
- 将干预措施定制为特定的OA表型提供了一种有希望的方法,以改善患者的治疗结果.
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