尼古丁通过α7 nAChR增加BDNF水平来改善工作记忆:来自临床和临床前研究的证据
Yingyan Li1,2,3,4,5, Xin Li2, Yaning Fu1,2,5
1China National Tobacco Quality Supervision &Test Center, Zhengzhou 450000, China.
概括
烟草中的尼古丁可以通过增加脑衍生神经营养因子 (BDNF) 水平来改善记忆和认知功能. 这种作用通过α-7尼古丁性乙胆受体 (α7 nAChR) 进行介导.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 认知科学 认知科学
背景情况:
- 吸烟与负面的健康结果有关,但尼古丁可能提供认知益处.
- 以前的研究表明,吸烟,来自大脑的神经营养因子 (BDNF) 和认知功能之间存在联系.
- 尼古丁对BDNF和认知的确切影响机制尚不清楚.
研究的目的:
- 研究尼古丁对认知功能的影响,特别是空间记忆.
- 探索大脑衍生神经营养因子 (BDNF) 在调解尼古丁效应中的作用.
- 阐明涉及α-7尼古丁性乙胆受体 (α7 nAChR) 的神经生物学机制.
主要方法:
- 在人类烟草使用者中评估血BDNF和空间记忆 (N-back测试).
- 在老鼠中建立了急性和慢性尼古丁暴露和戒断模型.
- 在血清,脑脊液和海马体中测量BDNF水平;评估空间记忆 (Y-迷宫) 和运动能力.
- 利用药理学阻断和α7 nAChR的遗传淘汰来证实它的作用.
主要成果:
- 烟草产品的使用增加了人类的工作记忆和血BDNF水平.
- 尼古丁剂量依赖于血清和海马体的BDNF升高,改善记忆性能.
- 尼古丁戒断导致BDNF水平降低,记忆力受损.
- 抑制或遗传删除α7nAChR阻断了尼古丁诱导的BDNF升高.
结论:
- 尼古丁消费通过α7 nAChR增强空间记忆.
- 尼古丁通过α7 nAChR升级BDNF表达,从而改善空间记忆.
- 用尼古丁准α7 nAChR提供了增强认知功能的潜在机制.
更多相关视频
12:19Live Imaging of Nicotine Induced Calcium Signaling and Neurotransmitter Release Along Ventral Hippocampal Axons
Published on: June 24, 2015
9.0K
08:47Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration
Published on: February 10, 2012
13.4K
相关概念视频
01:23Drugs Acting on Autonomic Ganglia: Stimulants
1.3K
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
1.3K
01:27CNS Depressants: Alcohol and Nicotine
166
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
166
01:29Stimulants
154
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
154
01:15Cholinergic Receptors: Nicotinic
2.1K
Nicotinic receptors are ligand-gated ion channels that are activated by acetylcholine and nicotine. Upon activation, they cause a rapid increase in the permeability of cells to K+, Na+, and Ca2+, followed by depolarization and excitation. They are in the autonomic ganglia, skeletal neuromuscular junction, CNS, and adrenal medulla.
There are two types of nicotinic receptors: neuromuscular (NM/NM/N1) and neuronal (NN/NN/N2). The two families differ based on their location and selectivity to...
There are two types of nicotinic receptors: neuromuscular (NM/NM/N1) and neuronal (NN/NN/N2). The two families differ based on their location and selectivity to...
2.1K
01:30Attention-Deficit/Hyperactivity Disorder
34
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
34
01:21Drugs Affecting Neurotransmitter Release or Uptake
916
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
916