对配对测试的样本大小计算 使用p值和置信区间,当不给定差异标准偏差时
Shyam Vayyat1, Nilotpal Chowdhury2, Manish Goyal3
1Assistant Professor, Department of Physiology, Indira Medical College and Hospitals, Thiruvallur, Tamil Nadu, India, Orcid: https://orcid.org/0000-0002-3529-5705.
准确的样本大小计算对配对研究设计至关重要. 本研究表明如何确定与p值或置信区间差异的标准偏差,改进样本大小估计.
科学领域:
- 生物统计学 生物统计学
- 研究方法研究方法研究方法学
背景情况:
- 样本大小计算对于研究有效性至关重要.
- 当前的工具经常使用聚合标准偏差 (SDp) 进行配对设计,这可能不那么准确.
- 差异的标准偏差为配对样本大小提供了更精确的估计,但往往无法使用.
研究的目的:
- 用常见报告的统计数据来演示计算对设计中的样本大小的方法.
- 引导研究人员从p值或置信区间中推导差异的标准偏差.
- 提供使用R脚本来确定样本大小的实用示例.
主要方法:
- 描述统计方法来导出差异的标准偏差.
- 用实用的研究实例来说明方法.
- 为实现提供R脚本.
主要成果:
- 差异的标准偏差可以从p值或置信区间准确计算出来.
- 与使用聚合SD相比,这种方法为配对设计提供了更精确的样本大小估计.
- 提供的R脚本有助于应用这种方法.
结论:
- 研究人员可以提高对设计的样本大小计算的准确性.
- 使用p值或置信区间来找到差异的标准偏差是一种可行的方法.
- 该研究使研究人员能够进行更强大的研究,采用适当的样本大小.
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