探索儿童玩具中PAHs激活Keap1-Nrf2-ARE通路的研究
Jonas Lauenstein1, Simon van de Weyer1, Rasha Alsaleh1
1Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
Contact dermatitis
|March 15, 2025
概括
玩具中的多环芳 (PAH) 存在皮肤敏感化风险. 甲,甲和烯具有更高的风险,混合物表现出协同作用.
科学领域:
- 环境毒理学环境毒理学
- 皮肤病学 皮肤病学
- 化学风险评估 化学风险评估 化学风险评估
背景情况:
- 儿童对环境污染物的敏感性.
- 多环芳 (PAH) 在儿童玩具中很常见.
- 评估PAHs引起的皮肤敏感化风险至关重要.
研究的目的:
- 评估PAHs的皮肤敏感化潜力,使用KeratinoSens测定.
- 研究单个PAH及其混合物的Keap1-Nrf2-ARE通路的激活.
- 确定消费品中PAHs所带来的风险.
主要方法:
- 在人类角质细胞上进行KeratinoSens测定.
- 对15个单独的PAH和三元混合物的评估.
- 度添加模型和添加剂指数用于混合物分析的应用.
主要成果:
- 甲 (B[k]F) 显示出最高的功效,比甲 (B[a]P) 强34倍.
- 甲 (B[b]F),烯和B[a]P也显著激活了该途径.
- 多氧化混合物显示出协同效应,表明风险增加.
结论:
- B[k]F,B[b]F和烯可能比以前认为的具有更高的皮肤敏感性风险.
- 在PAH混合物中的协同效应需要考虑组合暴露.
- 调查结果为消费品,特别是玩具中PAHs的风险评估提供了信息.
关键词:
1‐Nrf2‐ARE 路径氨酸感应试验测定消费品是一种消费品.混合物 混合物 混合物 混合物聚环芳香碳化合物 聚环芳香碳化合物产品安全 产品安全风险评估 风险评估 风险评估皮肤敏感化 皮肤敏感化有协同效应的效应.更多相关视频
08:02Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
Published on: October 19, 2013
18.2K
05:27Gap Junctional Intercellular Communication: A Functional Biomarker to Assess Adverse Effects of Toxicants and Toxins, and Health Benefits of Natural Products
Published on: December 25, 2016
14.9K
相关概念视频
01:36Types of Toxins
1.6K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.6K
01:07MAPK Signaling Cascades
5.1K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
5.1K