在息疗法中使用非标签药物:德尔菲研究,以达成基于证据的治疗建议的共识
Stefanie Pügge1, Aleksandra Dukic-Ott1, Julian Baumgärtel1
1Department of Palliative Medicine, LMU University Hospital, Ludwig-Maximilians-University in Munich, Munich, Germany.
Palliative medicine
|March 15, 2025
概括
这项研究制定了基于共识的建议,建议在息治疗中使用非标签药物. 这些指南旨在改善医疗保健专业人员管理复杂药物需求的患者安全和治疗规划.
科学领域:
- 抚慰性医学是一种缓解性医学.
- 药理学 药理学是指药理学的学科.
- 基于证据的实践.
背景情况:
- 非标签药物使用在息治疗中很常见,在安全性,法律方面以及成本覆盖方面存在挑战.
- 医疗保健专业人员经常面临时间和资源的局限性,对这些用途进行彻底的文献审查和风险效益分析.
研究的目的:
- 开发,评估和建立对治疗建议的协议在成人息疗法的非标签使用药物的治疗建议.
- 提供关于未经批准的药物应用程序的知情决策框架.
主要方法:
- 一个在线的Delphi研究,涉及两轮专家评估.
- 一个由医生,药剂师和息护理护士组成的国际小组评估了基于证据的建议.
- 64到75名专家参与了建立共识的过程.
主要成果:
- 在68项建议中的64项达成共识,涵盖21种药物和14种特定应用.
- 关键领域包括施用途径和适用于诸如,支气管,异口症,,单,,胃衰竭和热等疾病的说明.
- 通过医疗保健专业人员的免费在线数据库,可以访问共识建议.
结论:
- 由于缺乏注册研究,许多非标签息治疗用途的未来药物批准不太可能.
- 基于共识的建议对于促进个性化治疗计划和促进对非标签处方采取更深思熟虑的方法至关重要.
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