瘤细胞粘膜皮质性瘤的腺癌
Prokopios P Argyris1, Paul E Wakely2
1Division of Oral and Maxillofacial Pathology, The Ohio State University College of Dentistry, Postle Hall, Room 2191, 305 W. 12th Ave, Columbus, OH, USA. argyris.2@osu.edu.
Head and neck pathology
|March 15, 2025
概括
本案例研究详细介绍了粘膜腺癌的细胞变体,一种罕见的唾液腺瘤. 通过成像,细胞学,组织学和分子测试的结合,诊断得到了确认,突出了其独特的特征.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 遗传学 遗传学 是一个
背景情况:
- 粘膜腺癌 (MEC) 是最常见的唾液腺恶性瘤.
- 瘤细胞变异的MEC是罕见的,并呈现出明显的组织病理特征.
- 准确的诊断对于适当的患者管理和预后至关重要.
研究的目的:
- 为了呈现一种细胞变异性粘膜性皮肤癌的病例.
- 描述其临床放射学,细胞学,组织病理学和免疫类型特征.
- 为了提供诊断的分子确认.
主要方法:
- 图像和精细针吸收 (FNA) 细胞学的一种体质量.
- 手术切除 (口腔切除和淋巴切除) 和组织病理学检查.
- 免疫组织化学 (IHC) 和光在位杂交 (FISH) 用于MAML2重新排列.
主要成果:
- 鉴定出一个具有可疑宫淋巴结的大型鼻质.
- 细胞学显示,细胞细胞具有增加的N/C比率.
- 组织病理学揭示了一个带有瘤细胞,焦点粘膜小囊,缺乏线粒活动和亡的有限瘤.
- 免疫组织化学对AE1/AE3,p63和p40呈阳性,对AR,GATA3,S100,SOX10和Her-2呈阴性.
- 鱼类证实了MAML2的重新安排.
结论:
- 瘤细胞变体MEC可以通过包括成像,细胞学,组织学,IHC和分子分析在内的综合方法来诊断.
- 这个案例说明了这种罕见瘤的关键诊断特征.
- 通过MAML2重组进行分子确认对于确诊至关重要.
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Serous glands produce watery secretions rich in digestive enzymes and proteins. The constituent cells of the serous gland have centrally located nuclei and eosinophilic secretory granules in the cytoplasm. The parotid gland is an example of a serous gland. It secretes saliva, which contains enzymes, such as lipases and...