EGFR表达对EGFR信号依赖性和适应性免疫对EGFR突变肺腺癌的影响
Masahiro Torasawa1, Tatsuya Yoshida2, Kouya Shiraishi3
1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan; Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
在EGFR突变肺腺癌 (EGFRm LUAD) 中,EGFR表达水平,而不仅仅是突变,影响瘤特征和患者的结果. 评估EGFR表达对于定制治疗策略至关重要.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 免疫学 免疫学 免疫学
背景情况:
- 肺腺癌 (LUAD) 中的EGFR突变并不总是与EGFR表达水平相关.
- 影响EGFR表达及其对EGFR突变LUAD瘤生物学影响的因素尚不清楚.
研究的目的:
- 研究EGFR表达水平与基因组特征,信号通路,瘤微环境和EGFR突变LUAD中的临床结果之间的关系.
- 探索EGFR突变LUAD中EGFR表达的异质性.
主要方法:
- 早期和晚期EGFR突变LUAD患者的整体外体和RNA测序.
- 将患者分为低EGFR表达或高EGFR表达群的分类,基于每百万的中位数转录.
- 对EGFR表达,基因组特征,EGFR信号传递,瘤微环境和临床结果之间的关联进行了回顾性分析.
主要成果:
- 较低的EGFR表达与较少的TP53共同突变,较少的EGFR放大和更多的亚克隆EGFR突变相关.
- 低EGFR表达组显示MAPK信号激活较少,但丰富了自适应性免疫反应途径和免疫炎症瘤微环境.
- 低EGFR表达有利于术后复发,但是晚期不对奥西默提尼布反应的危险因素.
结论:
- EGFR表达水平与EGFR信号传递和适应性免疫显著相关,影响EGFR突变的LUAD的临床结果.
- 多基因组分析显示了EGFR突变的LUAD的异质性,强调了评估EGFR表达以及治疗优化突变状态的重要性.
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