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基于流行病学和实验研究的双S和双F口服参考剂量 (RfD) 的推导

Jing Cao¹, Wenhua Ma², Yanpeng Gao³

¹Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, PR China; Guangdong Basic Research Center of Excellence for Ecological Security and Green Development, Key Laboratory of City Cluster Environmental Safety and Green Development, School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, PR China; The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou 511400, PR China.

Ecotoxicology and environmental safety

|March 15, 2025

概括

双A (BPA) 替代品,双S (BPS) 和双F (BPF) 已经建立了新的口服参考剂量 (RfD). 这些毒性值低于BPA的毒性值,但高于目前的国际准则.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
内分泌学在内分泌学.

背景情况:

对双甲 (BPA) 的限制导致其类似物在环境中的存在增加.
由于广泛使用BPA替代品,缺乏确定的毒性值,健康问题越来越严重.
双S (BPS) 和双F (BPF) 是常见的BPA替代品,需要进行安全评估.

研究的目的:

为了获得双S (BPS) 和双F (BPF) 的口服参考剂量 (RfD).
为这些BPA替代品建立科学支持的毒性值.
为监管机构提供数据,以改善BPA替代品的安全指南.

主要方法:

对BPS和BPF的流行病学和动物研究进行系统的文献搜索.
基准剂量软件 (BMDS) 用于模型装配和确定基准剂量下限 (BMDL).
纳入男性精液质量下降作为确定出发点 (POD) 的关键影响.
不确定性分析来导出最终的RfD值.

主要成果:

对BPS和BPF的口服参考剂量 (RfD) 分别确定为0.37和8.09 ng/kg-bw/day.
对于BPS和BPF的推导RfD值低于BPA的确定的RfD值.
新的RfD值超过BPA目前的国际最低毒性值.

结论:

这项研究为确定BPS和BPF的毒性值提供了关键的科学证据.
由此产生的RFD为国际环境卫生监管机构提供了重要的参考资料.
强调需要在环境卫生政策中更加关注BPA替代品的安全性.

关键词:

基准剂量的基准剂量双二醇 F 是一种双二醇双 S 是一种双醇.人类暴露的人类暴露.通过口服进行暴露.参考剂量是指参考剂量.

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