检测儿童多发性硬化症的认知衰退:个人测量对高成就者的重要性
Noa Gur1, Dan Hoofien2, Tammy Pilowsky Peleg1
1Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel; The Neuropsychological Unit, Schneider Children's Medical Center, Petach Tikvah, Israel.
Multiple sclerosis and related disorders
|March 15, 2025
概括
在小儿多发性硬化症患者的认知衰退 (Personal-CD) 的一个新的个人测量方法揭示了标准测试中错过的微妙衰退,特别是在高成绩者中. 这些变化与抑郁症有关,而不是疾病严重程度.
科学领域:
- 神经科学是一个神经科学.
- 儿科神经学 儿科神经学
- 认知心理学 认知心理学
背景情况:
- 儿科发病多发性硬化症 (POMS) 对认知评估提出了独特的挑战.
- 标准认知障碍 (CI) 措施可能无法捕捉POMS中微妙的,个性化的认知变化.
- 评估相对于病前能力的认知衰退对于理解功能影响至关重要.
研究的目的:
- 在POMS患者中研究个人认知衰退 (Personal-CD) 测量的实用性.
- 将个人CD与基于规范数据的标准CI定义进行比较.
- 探索认知变化,学业表现和心理因素之间的关联.
主要方法:
- 这是一项31名POMS患者 (平均年龄15.8岁) 的队列观察研究.
- 在六个认知领域进行神经心理评估.
- 关于焦虑和抑郁的心理问卷;学术卓越和典型绩效组之间的比较.
主要成果:
- 在26%的参与者中发现认知障碍 (CI),与疾病残疾有关.
- 在45%的个人中发现了个人CD,特别是在高成就者中 (73%).
- 个人CD与抑郁症相关 (p=.01),而不是疾病严重程度.
结论:
- 个人CD检测了标准CI忽略的认知衰退,特别是在高成绩的POMS患者中.
- 在POMS的认知变化与抑郁症状有关,而不仅仅是疾病的严重程度.
- 个人CD强调了心理困扰对POMS认知功能的影响.
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