有氧运动训练,生物年龄和慢性心力衰竭的死亡率与减少的射出分数
Zihao Huang1, Xinghao Xu2, Yan Leng1
1Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
JACC. Advances
|March 15, 2025
概括
基于生物标志物的生物年龄 (BA) 预测了心力衰竭的死亡率与减少喷射率 (HFrEF). 在这些患者中,有氧运动训练 (AET) 可能会降低与衰老相关的死亡风险.
科学领域:
- 心脏病学 心脏病学
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 慢性心力衰竭与减少喷射率 (HFrEF) 构成显著的死亡风险.
- 基于生物标志物的生物年龄 (BA) 对HFrEF死亡率的预测价值尚未得到充分确立.
- 有氧运动训练 (AET) 对HFrEF中BA-死亡率关联的潜在修改效应需要研究.
研究的目的:
- 确定HFrEF患者的生物年龄 (BA) 和死亡率之间的关联.
- 评估有氧运动训练 (AET) 是否影响BA和死亡结果之间的关系.
- 评估BA在HFrEF中对所有原因死亡率,心血管死亡和住院治疗的预测能力.
主要方法:
- 利用了来自HF-ACTION试验的数据,包括1,732名参与者.
- 使用克莱梅拉 - 杜巴尔方法计算生物年龄加速 (BAA),基于BA和时间年龄的线性模型的余数.
- 使用考克斯的比例危险模型,研究了BAA (连续和五分位数) 和死亡率/住院终点之间的关联.
主要成果:
- 在BAA的1-SD增加与所有原因死亡率 (HR: 1.31) 和心血管死亡率 (HR: 1.31) 的31%更高风险相关.
- 在BAA的1-SD增加与所有原因住院的9%更高的风险有关 (HR:1.09).
- 与常规护理组相比,AET组中BAA和全因死亡率之间的关联显著减弱 (P相互作用=0.024).
结论:
- 基于生物标志物的生物年龄 (BA) 证明了HFrEF患者的死亡率和住院终点的显著预测价值.
- 有氧运动训练 (AET) 可以减轻与HFrEF患者的生物衰老相关的死亡风险增加.
- 在HFrEF管理中,BA作为一种有价值的预后生物标志物.
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