对HCC的新标准:TACE-免疫疗法组合的高风险
Antonio D'Alessio1, Lorenza Rimassa2
1Department of Surgery & Cancer, Imperial College London, London, UK.
Med (New York, N.Y.)
|March 15, 2025
概括
通过动脉化学栓塞 (TACE) 与免疫疗法相结合,已显示改善了中期肝细胞癌 (HCC) 的无进展生存率. 需要对这些新的TACE组合的患者选择和毒性进行进一步的研究.
科学领域:
- 肝胆瘤学 肝胆瘤学
- 干预性放射学 干预性放射学
- 医学瘤学 医学瘤学
背景情况:
- 超动脉化学栓塞 (TACE) 是中期肝细胞癌 (HCC) 的标准治疗方法.
- 系统疗法的近期进展促使TACE在组合疗法中重新评估.
- 两个主要的第三期试验已经引入了TACE的新型组合疗法.
研究的目的:
- 审查最近的第三期试验对中期HCC的TACE治疗模式的影响.
- 评估TACE与新型全身性药物结合的疗效和安全性.
- 确定有关患者选择和毒性的进一步研究领域.
主要方法:
- 来自EMERALD-1和LEAP-012临床试验第三阶段数据的分析.
- 在接受TACE加免疫治疗和单独接受TACE的患者中,无进展生存 (PFS) 的比较.
- 评估与组合疗法相关的不良事件和毒性概况.
主要成果:
- 在EMERALD-1试验中,TACE加上杜尔瓦卢马布/贝瓦齐祖马布的治疗改善了PFS.
- 在 LEAP-012 试验中,TACE 加上 pembrolizumab/lenvatinib 治疗改善了 PFS.
- 这两项试验都显示出显著的益处,但也引发了关于最佳患者选择和毒性管理的问题.
结论:
- 与新型免疫疗法结合使用TACE,代表了中期HCC的新标准.
- 进一步的研究对于完善这些组合疗法的患者选择标准至关重要.
- 仔细监测和管理毒性对于安全有效地使用TACE加免疫疗法至关重要.
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The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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