饮食时间通过调节脂肪细胞AMPKα2信号传递的脂肪肌肉交叉调节来增强运动
Jianghui Chen1, Jing Xiang1, Meiyu Zhou1
1Department of Cardiovascular Medicine, Center for Circadian Metabolism and Cardiovascular Disease, Southwest Hospital, Army Medical University, Chongqing 400038, China; Ministry of Education Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease, Chongqing 400038, China.
Cell metabolism
|March 15, 2025
概括
限日食 (DRF) 通过调节脂肪组织节律,影响炼. 脂肪细胞AMPKα2信号传递对于协调脂肪和肌肉新陈代谢至关重要,增强身体耐力.
科学领域:
- 代谢和分子生物学的代谢和分子生物学.
- 时间生物学 时间生物学
- 运动生理学 运动生理学
背景情况:
- 食节奏会影响运动表现和能量代谢.
- 在食节奏下控制脂肪细胞功能的机制尚不清楚.
研究的目的:
- 为了研究日限养 (DRF) 如何影响白色脂肪组织中的白天节律.
- 阐明脂肪细胞AMPKα2信号在调节新陈代谢协调和运动表现中的作用.
主要方法:
- 在小鼠淋巴腺白脂肪组织 (GWAT) 中进行了包括 (基) 蛋白质和脂质组在内的多组组学分析.
- 脂肪细胞特异性的Prkaa2 (编码AMPKα2) 的淘汰和体力耐力的评估.
- 对基因表达,脂质组,血清代谢物和肌肉钟基因的分析.
- 使用AMPK激活剂 (C29) 评估其对耐力的影响.
主要成果:
- 在GWAT中,DRF在线粒体蛋白质组,中性脂质组和营养感应途径中建立了白天节律.
- 脂肪细胞特异性Prkaa2缺乏会损害身体耐力,这与破坏的-CoA代谢和脂质组节律性有关.
- 脂肪细胞中的prkaa2影响肌肉钟基因和乳酸盐和糖酸盐等血清代谢物的昼夜重塑.
- AMPK激活剂C29以时间依赖的方式增强耐力和肌肉功能,这取决于脂肪细胞AMPKα2.
结论:
- 脂肪细胞AMPKα2信号传递是脂肪组织和肌肉之间的昼夜代谢协调的关键调节者.
- 这种信号通路对于优化炼表现和在食节奏下能量代谢至关重要.
关键词:
这就是AMPKK.脂肪细胞的脂肪细胞.脂肪组织的脂肪组织.时间医学 - - 时间医学.昼夜时间表的生物钟.昼夜节律 昼夜节律一天限量的养.运动生理学 运动生理学食节奏 食节奏多种主题的多种主题.更多相关视频
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