相关实验视频
Updated: May 22, 2025

08:17
Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
Published on: February 20, 2017
14.3K
非古典单细胞与左心室透静功能障碍和心力衰竭的功能标志物有关,具有保存的喷射分数
Elise L Kessler1, Elisa Dal Canto2, Ernest Diez-Benavente3
1Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Laboratory for Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands; Utrecht Regenerative Medicine Center, Circulatory Health Laboratory, University, Utrecht, the Netherlands.
International journal of cardiology
|March 15, 2025
概括
肥胖和糖尿病等炎症性疾病与心力衰竭有关. 这项研究发现,特定的单细胞亚型与左心室扩张性功能障碍 (LVDD) 和心力衰竭与保留射出分数 (HFpEF) 相关.
科学领域:
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
- 分子生物学分子生物学
背景情况:
- 以炎症为特征的肥胖和糖尿病与中级/非经典单细胞激活有关.
- 这种单细胞激活有助于左心室扩张性功能障碍 (LVDD) 和心力衰竭与保留喷射分数 (HFpEF).
研究的目的:
- 调查循环单细胞亚型及其与LVDD和HFpEF的活性之间的关联.
- 探索免疫学标志物和心声回声学指标间的扩张功能障碍的关系.
主要方法:
- 对73名患有或没有LVDD/HFpEF的患者的外周血液单核细胞 (PBMC) 的分析.
- 流细胞计用于单细胞亚型表征和巨细胞极化评估.
- 细胞因子分泌的测量,基因表达的RNA测序,以及与心声回声数据的相关性.
主要成果:
- 与对照组相比,LVDD患者表现出明显较低的IN-6分泌量.
- HFpEF患者中介和非经典单细胞增加;LVDD/HFpEF巨细胞显示向M2极化转移.
- 较高的非经典单细胞计数与扩张功能受损相关 (较低的E'隔膜速度).
结论:
- LVDD和HFpEF与向非经典单细胞亚型的转变有关.
- 增加的非经典单细胞与扩张性损伤相关,突出显示了炎症在LVDD和HFpEF中的作用.
相关概念视频
Pathophysiology of Heart Failure
1.4K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.4K
Imbalances in Cardiac Output
1.3K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.3K

