肠道神经系统功能障碍是中枢神经系统疾病的驱动因素:神经疾病中的被遗忘的大脑
Orabi Hajjeh1, Islam Rajab2, Mohammad Bdair1
1Department Of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
肠道神经系统 (ENS),或"第二大脑",积极驱动神经系统疾病,如帕金森病和阿尔茨海默病. 针对ENS功能障碍为大脑健康和疾病提供了新的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 肠道神经系统 (ENS),肠道神经系统.
- 第二个大脑,第二个大脑.
- 调节胃肠功能,并通过肠-大脑轴 (GBA) 与中枢神经系统 (CNS) 进行通信.
- 在神经退行性和神经发育性疾病中,包括帕金森病,阿尔茨海默病和自闭症谱系障碍中,内脏神经系统功能障碍越来越被认可.
- 致病机制包括改变的神经传递,肠道微生物群失衡和神经炎症,影响肠道和大脑健康.
研究的目的:
- 审查ENS作为一个积极的驱动器的作用,而不仅仅是一个标记,在神经系统疾病.
- 突出针对ENS功能障碍和GBA调节的新兴治疗策略.
- 在理解ENS在神经退行和神经发育障碍中的基本作用方面提出一个范式转变.
主要方法:
- 文献综述整合了ENS生物标志物,治疗点和GBA调制方面的进展.
- 分析GBA (阴道神经,荷尔蒙,免疫信号,微生物代谢物) 中的双向通信通路.
- 检查ENS参与诸如刺激性肠综合征 (IBS) 和炎症性肠病 (IBD) 等疾病的情况.
主要成果:
- 肠胃神经系统功能障碍是神经退行性和神经发育障碍的发病的一个基本机制.
- GBA促进了沟通,将肠道健康与神经功能和病理联系起来.
- 新兴的治疗方法,如益生菌,益生菌,FMT和迷走神经刺激,对调节肠-大脑相互作用显示出有前途.
结论:
- 肠神经系统是神经疾病的关键,活跃的参与者,超越了作为被动标记物的传统观点.
- 针对ENS和GBA提供创新的诊断和个性化治疗方法,用于大脑健康和疾病.
- 这种观点的转变有助于更深入地了解ENS在全身和中枢神经系统健康中的重要作用.
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