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产前聚乙烯纳米颗粒暴露对后代肺部发育的性别特异性影响

Wenxia Bu¹, Mengjiao Yu¹, Xinyi Ma¹

¹Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China.

Toxicology letters

|March 15, 2025

概括

产前接触纳米塑料会损害后代的肺部发育,导致性别特异性影响. 这项研究强调了纳米塑料等环境污染物的胎儿健康风险.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
发展生物学发展生物学

背景情况:

纳米塑料是普遍存在的环境污染物.
产前暴露于环境污染物可能会对胎儿发育产生负面影响.
纳米塑料暴露与支气管肺形 (BPD) 之间的联系需要进一步研究.

研究的目的:

调查产前暴露于80nm聚乙烯纳米粒子 (PS-NP) 对后代肺部发育的影响.
探索PS-NP对肺部发育的潜在性别特异性影响.
阐明纳米塑料诱导的肺发育异常背后的机制.

主要方法:

怀孕的小鼠通过口腔喉吸收暴露在PS-NP中.
肺部发育在出生后的1,7和21天被评估.
分析包括出生体重,肺重量,膜化,表面活性蛋白表达,炎症,亡,纤维化和血管生成.

主要成果:

暴露于PS-NP会使雌性后代的出生体重降低,并使两性肺部体重增加21个PND.
膜发育在男性和女性后代中都有所减少.
雌性后代表现出破坏的表面活性蛋白表达,炎症,亡和纤维化.
男子后代表现出血管新生受损,有助于BPD风险.

结论:

产前纳米塑料暴露显著影响后代的肺部发育,以性别特定的方式.
在男性和女性中,纳米塑料诱导的肺部异常背后有不同的机制.
这项研究提供了聚乙烯纳米粒子跨代呼吸道毒性的证据.

关键词:

支气管肺部发育不良症纳米塑料是一种纳米塑料.他们有后代,有后代的后代.产前暴露在产前暴露.性差异性差异性差异性差异性差异性差异性差异性

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