疹 Candida glabrata 颠覆了细胞内流通,并调节了自,使其在人类上皮细胞中复制
Juan Castillo-Cruz1, Samara Palacios-Barreto2, Manuel Alejandro Mosso-Pani2
1Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Department of Microbiology, México City, Mexico; Instituto Politécnico Nacional, Escuela Superior de Medicina, Department of Graduate, México City, Mexico.
虫 (C. glabrata) 通过促进自身的吸收和逃避溶酶体,侵入宿主细胞. 激活自有助于控制细胞内C. glabrata的生长,这表明这种宿主防御机制的关键作用.
科学领域:
- 微生物学 微生物学
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- 虫 (Candida glabrata) 是一种机会性真菌病原体,会引起严重的全身感染.
- 通过非食细胞内部化C. glabrata的机制及其细胞内生存并未得到充分理解.
研究的目的:
- 研究C. glabrata在上皮细胞内化的机制.
- 为了阐明宿主细胞内C. glabrata的细胞内命运.
- 探索宿主细胞自在C. glabrata感染中的作用.
主要方法:
- 研究了C. glabrata在上皮细胞中的吸收,使用显微镜观察actin和微管的参与.
- 分析了C. glabrata的细胞内贩运,包括 lysosomal 融合和复制.
- 评估了C. glabrata感染对宿主细胞自的影响.
- 研究了宫外自激活对细胞内真菌负担的影响.
主要成果:
- 甲状腺细胞内在化部分取决于actin和微管组织的重新排列.
- C. glabrata 积极促进宿主细胞对其自身的吸收.
- 酵母通过避免与溶解体的融合而在细胞内生存和复制.
- 在感染早期,C. glabrata降低了宿主自的调节,与其复制相关联.
- 实验性增强自减少了细胞内C. glabrata的生长.
结论:
- C. glabrata 操纵宿主内细胞和细胞内贩运通路,以进行入侵和生存.
- 宿主细胞自在控制细胞内C. glabrata增殖方面发挥着至关重要的作用.
- 向或增强自是一种针对C. glabrata感染的潜在治疗策略.
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