与老年人发病的炎症性肠病中与年龄和疾病相关的并发症和死亡率的风险 - 一项基于人口的研究
Dana Ben Hur1, Guy Issaschar2, Ran Moshe2
1Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel; Department of Internal Medicine H, Rambam Health Care Campus, Haifa, Israel.
概括
老年发病的炎症性肠病 (IBD) 患者面临的死亡率和并发症风险与一般老年人群相似. 然而,与成人IBD患者相比,他们患腹部手术的风险更高.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 老年病的医生 老年病的医生
背景情况:
- 炎症性肠病 (IBD) 可以在老年人 (老年发病IBD或EO-IBD) 中表现出来.
- 了解与EO-IBD相关的特定风险对于适当的患者管理至关重要.
研究的目的:
- 调查EO-IBD患者与年龄有关的并发症,死亡率和IBD相关手术的风险.
- 将这些风险与年龄相匹配的非IBD个体和成人发病IBD (AO-IBD) 患者进行比较.
主要方法:
- 一项使用以色列Epi-IIRN数据库 (2005-2020) 的全国性队列研究.
- 患有EO-IBD (≥65岁) 的患者与匹配的非IBD对照和匹配的AO-IBD患者 (18-65岁) 进行了比较.
- 统计模型 (累积发病率函数,比例分区危险) 用于评估结果.
主要成果:
- 与非IBD对照组相比,EO-IBD患者的死亡率和肺炎,骨折和血栓塞栓症的风险与非IBD对照组相似.
- 与EO-IBD患者相比,EO-IBD患者对提奥普林和抗TNF药物的暴露率较低.
- 与AO-IBD患者相比,EO-IBD患者的腹部手术风险更高 (特别是性结肠炎),但围手术风险更低 (克罗恩病).
结论:
- 与普通老年人相比,老年人发病的IBD不会增加死亡或常见的与年龄有关的并发症的风险.
- 与成人发 IBD 患者相比,EO-IBD 患者面临腹部手术的风险增加,但与成人发 IBD 患者相比,腹周手术没有风险增加.
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