9岁儿童的淋巴结转移呈现为粘膜皮质性癌症:一个病例报告
Ahmed Ahmed1, Sibel Ak2, Sara Amin2
1Department of Pathology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA Ahmed.a.ahmed@uth.tmc.edu.
Annals of clinical and laboratory science
|March 15, 2025
概括
这项案例研究突出显示了一种罕见的儿科粘膜皮质癌 (MEC),以部质量与淋巴结转移的形式呈现. 尽管很罕见,但儿科MEC显示出极好的生存率,类似于成人病例.
科学领域:
- 儿科瘤学 儿科瘤学
- 头部病理学 头部病理学
- 唾液腺新生体 唾液腺新生体
背景情况:
- 唾液腺瘤在儿童和青少年中不常见.
- 粘膜皮质腺癌 (MEC) 是最常见的恶性唾液腺瘤,通常以无痛的腺胀的形式出现.
- 宫淋巴结转移作为儿科MEC的初始表现是非常罕见的.
研究的目的:
- 报告一个罕见的儿科粘膜皮质癌 (MEC) 病例,最初出现宫淋巴结转移.
- 讨论儿童患者这种罕见表现的诊断结果和临床影响.
主要方法:
- 一个9岁的女性呈现了两个月的部质量史.
- 图像检测显示了一种异质的软组织质量,最初怀疑是的淋巴结.
- 淋巴结的组织学检查证实了转移性癌症,免疫组织化学 (IHC) 和PET-CT进一步描述了瘤及其主要来源于腺.
主要成果:
- 部质量的组织病理学显示,转移性癌瘤由表皮细胞和产生素的细胞组成.
- 免疫组织化学检测结果对泛细胞素,p40和p63呈阳性,焦点表达是木西卡明.
- 随后的PET-CT扫描发现了右侧腺的病变,与初级MEC一致.
结论:
- 儿科MEC可以异常呈现,淋巴结转移作为主要表现.
- 儿科MEC的IHC和分子概况与成人病例相似.
- 儿科MEC的预后是有利的,报告的五年生存率约为95%.
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