相关实验视频

Updated: May 22, 2025

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

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干扰素反应基因评分与青少年皮肤肌肉炎疾病活动之间的相关性

Jayne M MacMahon1, Mohammad Massumi2, Trang T Duong3

  • 1J.M. MacMahon, MB BCh BAO, Division of Rheumatology, The Hospital for Sick Children, and Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, and Child Health Evaluative Sciences, SickKids Research Institute.

The Journal of rheumatology
|March 15, 2025
PubMed
概括

1型干扰素 (IFN) 响应基因 (IRG) 评分与青少年皮肤肌炎 (JDM) 的疾病活性相关. 这一发现在疾病的早期和随着时间的推移都适用,这表明IRG得分是潜在的JDM生物标志物.

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The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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