免疫检查点抑制剂和怀孕:用最好的可用疗法治疗医疗复杂患者的考虑因素
1Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Seminars in perinatology
|March 15, 2025
概括
怀孕期间的癌症治疗是复杂的,特别是免疫检查点抑制剂 (ICI). 有限的数据显示,大多数活产儿不受影响,但罕见的新生儿并发症需要谨慎和进一步研究.
科学领域:
- 在瘤学瘤学.
- 生殖医学 生殖医学
- 免疫学 免疫学 免疫学
背景情况:
- 怀孕期间生育年龄和癌症诊断的平均年龄增加.
- 辅助生殖技术的增加和早期的癌症发病.
- 免疫检查点抑制剂 (ICI) 在癌症治疗中的使用越来越多.
研究的目的:
- 探索在怀孕期间使用免疫检查点抑制剂 (ICI) 的安全性和影响.
- 审查目前关于ICI在孕妇癌症患者使用的证据.
- 突出临床决策中的挑战,并倡导进一步的研究.
主要方法:
- 对临床前动物研究的审查.
- 分析已发表的关于ICI在怀孕期间使用的病例报告.
- 探索潜在的风险和利益.
主要成果:
- 现有的数据有限,主要来自动物研究和病例报告.
- 大多数报告的活产婴儿没有显著的不良影响.
- 已记录出严重新生儿并发症和免疫相关不良事件 (irAEs) 的孤立病例.
结论:
- 怀孕期间ICI的安全数据很少,需要谨慎的临床应用.
- 风险效益评估和知情的患者讨论至关重要.
- 进一步的研究是必不可少的,以制定明确的指导方针,ICI在怀孕期间使用.
关键词:
癌症 癌症 癌症 癌症ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI IC1 ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI ICI IC1 IC1 IC1 IC1 IC1 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 IC2 which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which免疫检查点抑制剂 免疫检查点抑制剂怀孕 怀孕 怀孕 怀孕更多相关视频
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