2019年冠状病毒疾病的药理治疗和管理
Amy Hirsch Shumaker1, Adarsh Bhimraj2
1Department of Pharmacy, VA Northeast Ohio Healthcare System, OH, USA; School of Medicine, Case Western Reserve University, OH, USA.
广泛的疫苗接种和Omicron变种已经降低了严重的COVID-19病例. 然而,高风险患者仍然需要针对2019年轻度至中度冠状病毒病 (COVID-19) 进行个性化治疗.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 广泛的疫苗接种,混合免疫力和Omicron变异特征已经减少了2019年冠状病毒严重疾病 (COVID-19) 在一般人群中.
- 然而,特定的患者群体仍然面临严重COVID-19结局的高风险.
- 目前针对严重和危急的COVID-19的治疗指南在近年来得到了有限的更新.
研究的目的:
- 审查当前COVID-19治疗策略的情况.
- 强调在轻度至中度的COVID-19中需要个性化治疗方法.
- 讨论在Omicron时代免疫调节剂的不断变化的作用和最佳时间.
主要方法:
- 审查当前的文献和临床指南.
- 对COVID-19管理中的免疫调节剂数据的分析.
- 考虑变种特异性特征和人口免疫力.
主要成果:
- 在一般人群中,由于疫苗接种和Omicron变种,严重的COVID-19结局的发生率降低.
- 确定患有严重疾病高风险的患者子组.
- 建立了针对严重/危急COVID-19的指导方针导向疗法,并正在对免疫调节剂进行研究.
结论:
- 对于患有轻度至中度COVID-19的患者来说,个性化治疗至关重要,平衡好处和危害.
- 虽然对免疫调节剂的理解已经增长,但它们在Omicron时代的确切作用和时间需要进一步澄清.
- 持续的研究是必要的,以完善严重和关键的COVID-19的管理策略.
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