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Updated: May 22, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
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含有1 (LACC1) 的Laccase域中的克罗恩病相关变体调节T细胞基因表达,代谢和T细胞功能

Yingcong Li1,2, Gabriel Ascui1,3, Martina Dicker1

  • 1La Jolla Institute for Immunology, La Jolla, CA, USA.

Nature communications
|March 16, 2025
PubMed
概括

靠近LACC1基因的遗传变异会影响其在T细胞中的表达,影响细胞代谢和功能. 这项研究揭示了将LACC1变体与克罗恩病 (CD) 和大肠炎联系在一起的机制.

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