心脏生物标志物预测新生儿脑病变中右心室的低性能
Shiran Sara Moore1,2,3, Anie Lapointe4, Emmanouil Rampakakis1,3
1Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada.
概括
在脑病变的新生儿中,肌酸激酶 (CK) 和心脏素-I (CTn-I) 的升高与治疗性低温期间右心室功能减弱相关.
科学领域:
- 新生儿心脏病学 新生儿心脏病学
- 儿科重症监护医药 儿科重症监护医药
- 生物标志物研究的研究.
背景情况:
- 新生儿脑病变 (NE) 对新生儿构成重大风险.
- 治疗性低温 (TH) 是对NE的标准治疗方法.
- 在NE患者中,心室性能需要仔细监测.
研究的目的:
- 调查心脏生物标志物和心声回声测量新生儿内腔表现与NE之间的关系.
- 评估特定生物标志物的实用性,以预测右心室功能受损.
主要方法:
- 在2016年至2021年期间,对56名接受TH治疗的新生儿进行前性观察研究.
- 在生命的第2,3,4和10天进行重复心声和生物标志物测量 (CK,CTn-I).
- 使用皮尔森相关性和通用线性混合效应模型的统计分析;用于诊断准确性的ROC曲线.
主要成果:
- 肌酸激酶 (CK) 和心脏素-I (CTn-I) 水平与右心室 (RV) 功能有显著的关联.
- CK (1961 U/L) 和CTn-I (91 ng/L) 的特定值预测了高灵敏度的低三 annular 平面缩外流 (<7 mm).
结论:
- 升高的CK和CTn-I水平表明新生儿的RV性能下降,NE接受TH.
- 监测这些生物标志物可以帮助识别RV功能改变的新生儿,并指导TH期间的心声评估.
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