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Updated: May 22, 2025

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
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Shank3通过mGlu5调节Rpl3表达和蛋白质合成:对Phelan McDermid综合征的影响

Federica Giona1, Stefania Beretta1,2, Antonio Zippo1

  • 1CNR, Neuroscience Institute, Milano, Italy.

Molecular psychiatry
|March 16, 2025
PubMed
概括

克3基因突变损害了蛋白质合成,导致自闭症谱系障碍和菲兰·麦克德米德综合征症状. 恢复核糖体蛋白Rpl3的表达减轻了这些缺陷在小鼠模型.

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