在患有活跃系统性结核病的患者和没有活跃疾病的干扰素玛释放试验阳性患者中比较膜炎的表现
Ikhwanuliman Putera1,2,3,4, Aniki Rothova2, Rina La Distia Nora5,6
1Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Eye (London, England)
|March 16, 2025
概括
与活跃结核病 (TB) 相关的尿道炎在年轻患者中经常表现为典型的眼部结核病表现. 不典型的表现可能发生在老年人或没有活跃结核病的人身上.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 尿道炎是一种复杂的眼内炎症,具有不同的病因.
- 结核病 (TB) 是一种重要的系统性感染,可以影响眼睛,导致眼睛结核病 (OTB).
- 从其他原因区分结核病相关的膜炎对于有效的管理至关重要.
研究的目的:
- 为了研究活跃的全身结核病患者的毛囊炎的临床特征.
- 为了将这些表现与膜炎患者进行比较,这些患者对干扰素-释放试验 (IGRA) 呈阳性,但缺乏活跃的全身结核病.
- 在眼液中分析阳性Mycobacterium结核病 (Mtb) 聚合酶链反应 (PCR) 患者,但没有系统性结核病.
主要方法:
- 对118名患有紫外线炎的患者进行了回顾性分析.
- 将其分为三组:活跃的全身结核病,没有活跃结核病的IGRA阳性脑膜炎和没有活跃结核病的Mtb PCR阳性眼液.
- 人口统计数据,眼科发现和系统性结核病调查的比较.
主要成果:
- 活跃的结核病相关性脑膜炎主要影响年轻患者.
- 典型的OTB表现在活跃结核病例中更频繁 (p < 0.001) 并与年轻年龄相关 (p = 0.002).
- 没有系统性结核病的MTB PCR阳性眼液患者的眼部发现与活跃结核病患者的眼部发现相似,包括冠状腺颗粒瘤. 没有活跃结核病的IGRA阳性患者年龄较大,具有非典型特征.
结论:
- 与活跃结核病相关的尿道炎通常表现为具有特征的OTB症状,特别是在年轻人中.
- 结核病应在脑膜炎的差异诊断中考虑,特别是在年轻的患者中.
- 在老年患者或没有并发性活跃结核病的患者中,非典型的脑膜炎表现可能更为普遍.
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