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基于CT的放射性诺米克图 (CT-Based radiomics nomogram) 对肺部和中胸部特征进行鉴定,以鉴定慢性阻塞性肺部疾病中的心血管疾病:一项多中心研究

XiaoQing Lin^1,2, TaoHu Zhou¹, Jiong Ni³

¹Department of Radiology, Second Affiliated Hospital of Naval Medical University, No. 415 Fengyang Road, Shanghai, 200003, China.

BMC pulmonary medicine

|March 16, 2025

概括

基于CT的新型放射性纳米图有效地识别慢性阻塞性肺病 (COPD) 患者的心血管疾病 (CVD). 在临床因素和视觉冠状动脉评分上,Mediastinum放射学显示出优异的性能.

科学领域:

放射学放射学是一门学科.
心脏病学心脏病学
肺部病理学肺部病理学

背景情况:

心血管疾病 (CVD) 是慢性阻塞性肺部疾病 (COPD) 患者的重要并发症.
在COPD患者中准确识别心血管疾病对于有效管理至关重要.
当前的诊断方法在这个特定的患者群体中可能存在局限性.

研究的目的:

评估使用CT衍生放射性诺米克图谱的诊断模型在COPD患者中检测心血管疾病的有效性.
为了比较肺部和中胸部放射学诺米克图的性能,与传统的临床因素和视觉冠状动脉分数 (CACS) 相比.

主要方法:

用现有临床数据和CT扫描对住院COPD患者 (n=686) 的回顾性分析.
从肺和中中提取放射性特征,然后使用LASSO逻辑回归进行选择.
使用ROC曲线分析和DCA.与临床因素和视觉CACS相比,构建和验证放射学名图,使用ROC曲线分析和DCA.

主要成果:

介质体放射学名录达到了0.86的AUC,超过了肺放射学名录 (AUC0.79),临床因素 (AUC0.71) 和视觉CACS (AUC0.65).
开发的诺姆图表显示出在广泛的值概率范围内具有卓越的区分能力和临床实用性.
确定的主要临床预测因素包括年龄,中性粒细胞百分比,血红素和GOLD阶段.

结论:

基于胸部CT的放射性诺米克图,特别是那些来自中胸部特征的放射性诺米克图,为COPD患者的心血管疾病识别提供了增强的辨别能力.
这些放射学名图代表了一种有希望的非侵入性工具,用于改善这种脆弱人群中心血管疾病风险分层.
这些发现支持将放射学纳入常规临床实践,以更好地评估COPD的心血管风险.

关键词:

心血管疾病是什么心血管疾病慢性阻塞性肺病 (COPD) 是一种慢性阻塞性肺病.计算机断层扫描 (CT) 扫描冠状动脉中的 (CAC)无线电学 (Radiomics) 是一种无线电学.

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