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3D培养的生产和冷保存

N Moisieieva¹, O Gorina², A Moisieiev¹

¹Institute for Problems of Cryobiology and Cryomedicine of National Academy of Sciences of Ukraine, 23, Pereyaslavska Str., Kharkiv 61016, Ukraine.

|March 16, 2025

概括

三维 (3D) 培养系统,称为球体 (SPs),提供先进的体外模型. 本综述探讨了影响SP形成和冷保存的因素,旨在改善其在组织工程和药物测试中的使用.

科学领域:

生物技术是生物技术.
细胞生物学细胞生物学
组织工程是组织工程.

背景情况:

三维 (3D) 培养系统,包括球形 (SPs),模仿本地组织的复杂性.
SPs使得研究细胞间相互作用对生物过程至关重要.
目前的应用包括基础研究,组织工程和临床前药物测试.

研究的目的:

审查影响球形 (SP) 形成的因素,以提高标准化.
介绍关于增强球体 (SP) 生产方法的研究.
探索物理数学方法来优化SP冷保存.

主要方法:

影响球形 (SP) 形成的因素的审查.
对球体 (SP) 生产的理论方法的分析.
对冷保存的物理数学模型的评估.

主要成果:

确定了影响球状体 (SP) 形成和质量的关键因素.
突出了理论模型的潜力,以提高SP生产.
提供了改善球体 (SP) 冷保存协议的见解.

结论:

优化球状体 (SP) 生产和冷保存对于推进组织工程至关重要.
物理数学建模为改善球体 (SP) 冷保存提供了一个有希望的途径.
标准化的SP将扩大其在研究和临床前应用中的实用性.

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