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Updated: May 22, 2025

Visualizing DNA Damage Repair Proteins in Patient-Derived Ovarian Cancer Organoids via Immunofluorescence Assays
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向复制叉处理与PARP抑制协同作用,以在同源重组熟练的卵巢癌中增强致命性

Ganesh Pai Bellare1,2, Kshama Kundu1, Papiya Dey1

  • 1Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai, 400085, India.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|March 16, 2025
PubMed
概括

与多 (ADP-ribose) 聚合酶抑制剂 (PARPi) 结合的trans-4,4'-dihydroxystilbene (DHS) 显示出通过向复制应激和同源重组修复来治疗卵巢癌的前景. 这种组合有效地减少了瘤生长,毒性最小.

关键词:
复制DNA复制DNA复制DNA复制这是一种PARP抑制剂.在 ssDNA 中存在差距.塔拉索帕里比 (Talazoparib) 是一种可怕的药物.跨-4,4′-二氧乙烯 (DHS) 是一种

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