应对工程复合物专用代谢物通路在植物中的挑战
Sachin A Gharat1, Vaijayanti A Tamhane1,2, Ashok P Giri1,3,4
1Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, 7610001, Israel.
The Plant journal : for cell and molecular biology
|March 16, 2025
概括
代谢工程旨在促进植物代谢物生产. 本综述涵盖了途径阐明和工程策略,重点关注可持续代谢物合成的复杂途径.
科学领域:
- 植物生物化学和代谢工程.
- 合成生物学和生物技术.
背景情况:
- 植物产生有价值的特殊代谢物,但产量往往很低.
- 对本地植物系统的基因操纵具有挑战性.
- 异质系统 (微生物,无细胞) 提供了替代的生产平台.
研究的目的:
- 审查生物合成途径阐明和代谢工程方面的进展.
- 突出工程复杂,多基因植物通路的策略.
- 讨论途径重建的挑战和解决方案.
主要方法:
- 关于路径阐明技术的文献综述.
- 分析植物和微生物的代谢工程策略.
- 专注于复杂的途径重建,需要多个基因表达.
主要成果:
- 成功阐明路径对于有效的代谢工程至关重要.
- 工程复杂的路径,特别是稳定转换的工厂,仍然具有挑战性.
- 基于计算机的预测有助于路径阐明和工程.
结论:
- 途径阐明和工程方面的进步使得可持续的代谢物生产成为可能.
- 克服复杂路径重建中的障碍是关键.
- 代谢工程为生产有价值的植物化合物提供了有希望的解决方案.
相关概念视频
C4 Pathway and CAM
45.1K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
C4 Pathway
The C4 pathway is used by plants such as...
45.1K
Overview of Metabolism
29.4K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
29.4K
Defenses Against Pathogens and Herbivores
22.8K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
22.8K
Plant Breeding and Biotechnology
18.7K
Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
18.7K
Bioremediation
18.1K
Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
18.1K


