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Updated: May 22, 2025

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在自身免疫性疾病的发展过程中,ROS-依赖的SOCS3上调破坏了调节性T细胞的稳定性

Hiroki Satooka1, Yuzuki Nakamura1, Takako Hirata1

  • 1Department of Fundamental Biosciences, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.

Redox biology
|March 16, 2025
PubMed
概括

反应性氧物种 (ROS) 在类风湿性关节炎 (RA) 等自身免疫性疾病中破坏调节性T细胞 (Treg) 稳定性. 抗氧化剂通过抑制通过NADPH氧化酶2 (Nox2) 的ROS产生恢复Treg功能,这表明了一个新的治疗点.

关键词:
自身免疫性疾病是一种自身免疫性疾病.Nox2 没有2x2在 PTEN 氧化过程中.这就是ROSOS ROS.这是Tregs.

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