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在社会经济弱势社区加速分子衰老:种族/民族比较

Jennifer W Robinette¹, Jennifer A Smith²

¹Psychology Department, Chapman University, One University Drive, Orange, CA 92866, USA.

|March 16, 2025

概括

邻居的社会经济地位对种族/民族群体的表观遗传衰老有不同的影响,吸烟地位调解了这些差异. 解决基于地区的低社会经济地位的问题可能会改善不同人口的健康.

科学领域:

表观遗传学与公共卫生
社会流行病学社会流行病学
衰老研究研究衰老研究

背景情况:

美国的种族/民族健康差异与社会经济因素和社区特征有关.
表观遗传机制可能是社会经济地位 (SES) 和健康之间的关联的基础.
邻居对健康的影响可以因种族/种族而异.

研究的目的:

通过使用四个经过验证的表观遗传时钟,调查基于区域的SES和表观遗传年龄之间的关联.
检查这些关联是否在种族/种族群体 (非西班牙裔白人,非西班牙裔黑人,西班牙裔) 中存在差异.
探索吸烟身份在调解这些关系中的作用.

主要方法:

在健康和退休研究 (2016) 中利用了来自3790名老年人的数据.
基于地区的SES数据来自人口普查信息 (美国社区调查,2012-2016).
在基于区域的SES上回归了四个表观遗传时钟 (Horvath,Hannum,PhenoAge,GrimAge),控制共变量并检查与种族/种族之间的相互作用.

主要成果:

以较低面积为基础的SES与加速的PhenoAge和GrimAge有关,但不是Horvath或Hannum时钟.
在考虑到吸烟状态后,基于区域的SES和加速的GrimAge之间的关联仍然存在.
在非西班牙裔白人个体中,基于区域的SES显示出与加速的Hannum,PhenoAge和GrimAge有更强的关联,但当吸烟状态被纳入时,这些差异减少了.

结论:

表观遗传衰老模式和吸烟等行为风险与基于地区的SES具有种族/种族不同的关联.
针对低面积SES的干预措施可以在各种种族/民族群体中提供广泛的健康益处.
吸烟状态是影响邻居SES和表观遗传衰老之间的关系的关键因素.

关键词:

基因表观衰老基因表观衰老基因表观衰老种族/民族的差异.社会经济地位社会经济地位

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