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5 - 氨基氨酸酸通过增强精子线粒体功能来改善野猪精液质量
Shanpeng Wang1, Qi Wang1, Xuejun Zeng2
1College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China.
Theriogenology
|March 16, 2025
概括
饮食中补充5-阿米诺列武林酸 (5-ALA) 可以显著改善野猪精液质量和生殖性能. 250 mg/kg/d 5-ALA的最佳剂量可以增强精子的运动性,减少DNA损伤,并提高生育能力.
科学领域:
- 动物科学动物科学
- 生殖生物学 生殖生物学
- 生物化学 生物化学
背景情况:
- 5 - 氨基氨酸 (5-ALA) 是一种关键的代谢中间体,影响线粒体功能.
- 5-ALA对野猪生殖参数的影响的确切机制尚未完全理解.
研究的目的:
- 调查饮食中5-ALA补充剂对野猪精液质量的影响.
- 评估5-ALA对野猪生殖表现和潜在生理机制的影响.
主要方法:
- 四十五只野猪被分配到对照组或四个5-ALA剂量组之一 (125,250,500,1000毫克/公斤/天) 为期九周.
- 分析了精液质量,血清激素水平,新陈代谢和线粒体功能标志物.
- 评估了繁殖结果,包括生育率和 litter 特性.
主要成果:
- 5-ALA补充剂增加了精液量,精子数和运动性,同时减少了异常.
- 250 mg/kg/d的5-ALA剂量显著减少了精子DNA氧化损伤,提高了丸激素,并改善了线粒体功能 (ATP,OXPHOS活性).
- 生殖能力得到改善,活产率和生育率增加,木乃伊化胎儿减少.
结论:
- 食5-ALA,特别是250 mg/kg/d,通过优化精液等离子体代谢和精子线粒体功能来提高野猪精液质量.
- 5-ALA补充剂对野猪的繁殖性能产生了积极的影响,为提高猪养殖效率提供了可行的策略.
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