药物使用与医院感染之间的关联:一个多中心病例控制研究
1Department of Hospital Infection Management, The Second People's Hospital of Gansu Province, Affiliated Hospital of Northwest Minzu University, Lanzhou, Gansu Province, China.
某些药物,如质子抑制剂 (PPI),葡萄皮质类药物和H2受体对抗剂,增加了在医院获得感染 (HAI) 的风险. 长期使用这些药物进一步提高患者的HAI风险.
科学领域:
- 传染性疾病 传染性疾病
- 临床药房 临床药房
- 医院流行病学 医院流行病学
背景情况:
- 医院感染 (HAI) 对患者安全构成重大威胁.
- 了解HAI的风险因素对于制定有效的预防策略至关重要.
研究的目的:
- 调查药物使用与HAI发病率之间的关联.
- 确定可能增加HAI风险的特定药物类别.
主要方法:
- 追溯式,多中心病例控制研究设计.
- 包括604个HAI病例和604个来自中国三家医院的匹配对照.
- 使用多变量逻辑双项回归和趋势奇平方测试进行统计分析.
主要成果:
- 质子抑制剂 (PPI),葡萄糖皮质类药物和H2受体对抗剂与增加HAI风险显著相关.
- 针对PPI,葡萄糖皮质类药物和H2受体对抗剂的相对风险分别为1.37,1.33和1.84.
- 长时间使用PPI和葡萄糖皮质类药物与较高的HAI发病率相关.
结论:
- 葡萄糖皮质类药物,PPI和H2受体对抗剂与HAI的更高风险有关.
- 长时间使用这些药物加剧了风险.
- 短期使用抗生素 (长达10天) 与HAI获得没有关联.
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