在患有抑郁症状的成年人中使用酸性反流药物
Shakila Meshkat1, Qiaowei Lin2, Vanessa K Tassone3
1Interventional Psychiatry Program, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Journal of affective disorders
|March 16, 2025
概括
抑郁症与增加使用抗酸剂,H2RAs和PPI等酸性反流药物有关. 对于患有酸性反流症的患者来说,查抑郁症状至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 情绪压力和抑郁是胃食道逆流症 (GERD) 症状的潜在贡献者.
- 了解心理健康和GERD管理之间的关系对于全面的患者护理至关重要.
研究的目的:
- 评估抑郁症状之间的关联,它们的严重程度,以及使用酸性反流药物的症状集群.
- 调查基于性别的潜在相互作用对这些关联的影响.
主要方法:
- 利用了2007-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 包括31,444名成年参与者 (≥18岁),他们填写了关于抑郁症状和处方药使用的问卷.
- 员工调整的赔率比率 (aOR) 来评估协会,控制相关的共变量.
主要成果:
- 患有抑郁症状的参与者使用抗酸药,组胺-2受体对抗剂 (H2RAs) 和质子抑制剂 (PPIs) 的几率明显更高.
- 增加抑郁症状严重程度和特定症状集群 (认知-情感,体质) 与使用所有测试的酸性反流药物的更高几率有关.
- 没有观察到与药物使用相关的显著性相互作用效应.
结论:
- 抑郁症状与使用各种酸性反流药物有着显著的关联.
- 这些发现强调了在患有GERD或使用酸性反流治疗的人群中查抑郁症状的重要性.
- 进一步的研究可能会探索同时管理抑郁症和GERD的临床影响.
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