比较不同给药方法的亚麻醉性普罗波福尔减轻在接受日间手术的学龄前儿童出现动荡:双盲,随机对照研究
Jiaxiang Chen1,2, Xiaoli Shi3, Wei Hu3,4
1Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
BMJ paediatrics open
|March 16, 2025
概括
连续输注的propofol有效地降低了sevoflurane麻醉后学龄前儿童的出现动荡. 这种方法被证明比玻尿酸注射更有效,而不会增加唤醒时间.
科学领域:
- 麻醉学 麻醉学
- 儿科手术 儿科手术
背景情况:
- 在学龄前儿童中使用sevoflurane麻醉与高频率的突发动荡 (EA) 有关.
- 在吸入麻醉后的小儿科患者中,波的亚麻醉剂量可以减轻EA.
- 为了防止EA,波的最佳施用策略需要进一步研究.
研究的目的:
- 评估不同施用亚麻醉剂量普罗波的施用方法在预防学龄前儿童出现动荡时的有效性.
- 为了比较连续输注和玻尿酸注射之间出现动荡的发生率和严重程度.
- 评估普罗波福尔给药对输出管和出现时间的影响.
主要方法:
- 一项双盲试验,涉及160名学龄前儿童 (2-5岁) 在sevoflurane麻醉下进行腹腔镜 inguinal hernia修复.
- 参与者被随机分为四组:对照组,手术结束前3分钟的单次醇玻尿酸注射,手术结束时的单次玻尿酸注射,手术结束时3分钟的连续输液 (所有1mg/kg).
- 使用小儿麻醉突发 Delirium (PAED) 和Watcha尺度评估了突发动作.
主要成果:
- 与对照组 (65.0%),玻尿酸A (30.0%) 和玻尿酸B (32.5%) 组相比,连续输液组 (5.0%) 的出现动荡的发生率明显较低.
- 持续输液组表现出明显较低的PAED峰值得分.
- 两组之间没有观察到出时间或出现时间的显著差异.
结论:
- 在结束sevoflurane麻醉后,连续输注3分钟的低麻醉剂量propofol (1mg/kg) 在减少出现动荡方面更有效.
- 这种注射方法比注射肉囊更好,因为它可以有效地管理EA,而不会延长患者的出现.
- 这些发现支持持续的普罗波福尔输液作为预防儿科患者出现动荡的最佳策略.
相关概念视频
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