在接种COVID-19mRNA疫苗后,严重的狂犬病病病例需要脏替代疗法
Motohiro Ueda1, Kohei Uchimura1, Kie Ohkoshi1
1Department of Nephrology, Graduate School of Medicine, University of Yamanashi, Japan.
Internal medicine (Tokyo, Japan)
|March 16, 2025
概括
一名60岁的男子在接种了第四次COVID-19 mRNA疫苗后经历了严重的骨髓溶解和急性损伤 (AKI). 用血液过即时治疗导致功能完全恢复.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 毒理学 毒理学 毒理学
背景情况:
- 针对2019年新冠病毒病 (COVID-19) 的疫苗接种对于公共卫生至关重要.
- 免疫接种后的不良事件虽然很少发生,但需要进行彻底的调查.
- 轮骨髓溶解和急性损伤 (AKI) 是潜在的,尽管不常见的并发症.
研究的目的:
- 在接种COVID-19mRNA疫苗后,报告一例罕见的严重狂犬病和AKI病例.
- 以突出诊断挑战和治疗结果在这种情况下.
- 为了解潜在的疫苗相关不良事件作出贡献.
主要方法:
- 一个60岁的男性患者的病例报告.
- 临床表现:接种疫苗后两天的肌肉疼痛和无尿症.
- 实验室检查:肌激酶 (CK) 和血清肌的升高.
- 治疗方法:静脉注射治疗,然后在线血液过.
主要成果:
- 患者发生了严重的狂犬病溶解,CK水平达到16万 IU/L.
- 急性损伤 (AKI) 得到证实,血清肌素为6.59 mg/dL.
- 标准静脉注射治疗不足;在线血液过开始.
- 成功治疗导致CK水平正常化,功能完全恢复.
结论:
- 冠状病毒疾病2019 (COVID-19) mRNA疫苗接种可能与罕见但严重的不良事件有关,如狂犬病和AKI.
- 在线血液过是一种有效的治疗选择,用于管理疫苗诱导的狂肠分裂和AKI.
- 持续监测和报告疫苗接种后不良事件是必不可少的.
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