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相关概念视频

Salivary Glands and Saliva01:23

Salivary Glands and Saliva

341
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
341
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Biological Effects of Radiation02:59

Biological Effects of Radiation

15.1K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
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Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

171
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Tonsillitis II: Management01:26

Tonsillitis II: Management

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This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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相关实验视频

Updated: May 22, 2025

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
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Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction

Published on: April 24, 2016

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放射治疗相关的唾液功能障碍

Grace C Blitzer1, Cristina Paz2, Sara S McCoy3

  • 1Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI.; University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Seminars in radiation oncology
|March 16, 2025
PubMed
概括

辐射诱导的异口症 (RIX),头癌放射治疗的常见副作用,严重影响生活质量. 本综述涵盖了RIX量化,病理生理学以及当前/新兴治疗方法,以改善患者管理.

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Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics
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Murine Salivary Functional Assessment via Pilocarpine Stimulation Following Fractionated Radiation
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相关实验视频

Last Updated: May 22, 2025

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
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Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics
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Murine Salivary Functional Assessment via Pilocarpine Stimulation Following Fractionated Radiation
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科学领域:

  • 在瘤学瘤学.
  • 辐射疗法 辐射疗法
  • 唾液腺生物学 唾液腺生物学

背景情况:

  • 辐射诱导的异口症 (RIX) 是头癌放射治疗的普遍和衰弱的后果.
  • 由于唾液功能受损,RIX显著降低了患者的生活质量.

研究的目的:

  • 为了提供一个全面的辐射诱导的异口症综述.
  • 总结关于RIX量化,病理生理学和治疗策略的当前知识.

主要方法:

  • 临床量化方法 (客观和主观) 的文献综述.
  • 阐明辐射对唾液腺损伤的病理生理机制.
  • 对RIX的既定和新兴治疗干预措施的分析.

主要成果:

  • 存在各种方法来量化唾液流量和异口症严重程度.
  • 病理生理学包括直接辐射损伤,唾液成分变化和炎症.
  • 目前的治疗方法 (唾液替代品,兴奋剂) 有局限性;新型疗法显示出希望.

结论:

  • 对临床医生和研究人员来说,对RIX的彻底理解至关重要.
  • 需要进一步的研究,以制定更有效的预防和治疗策略RIX.
  • 开发改进的治疗方法将减轻癌症幸存者的异口症负担.