进入ICU的流感患者死亡风险:系统性审查和元分析
Pablo Suárez-Sánchez1, Jara Majuelos-Melguizo1, Marina Hinojosa-Campos1
1OXON Epidemiology, Madrid, Spain.
Influenza and other respiratory viruses
|March 16, 2025
概括
季节性流感对入住重症监护室 (ICU) 的患者产生重大影响. 这次审查发现,大约24%的流感的ICU患者经历了全因死亡率,突出了需要更好的预防和治疗策略的需要.
科学领域:
- 流行病学 流行病学
- 密集护理医学 密集护理医学
- 传染性疾病 传染性疾病
背景情况:
- 季节性流感带来了相当大的死亡风险,特别是在重症监护室 (ICU).
- 现有的关于ICU患者因流感死亡率的监测数据有限,并且显示出相当大的变化.
- 了解这种负担对于有效的治疗规划和重症监护机构的资源分配至关重要.
研究的目的:
- 进行系统的文献审查和元分析,以确定全因死亡风险.
- 调查2009年至2019年期间在欧洲因流感而入院ICU的患者的死亡率.
主要方法:
- 包括来自欧洲的观察性研究,报告了6个月及以上年龄的流感患者入院ICU的死亡率.
- 使用修改后的纽卡斯尔-太华尺度评估研究质量.
- 使用随机效应模型计算所有死因风险,并对低偏差风险研究进行敏感性分析.
主要成果:
- 包括37项涉及13,616名患者的研究;报告的全因死亡率从0%到67%不等.
- 总的聚合死亡风险估计为0.24 (95% CI:0.20,0.27),观察到高异质性.
- 对低偏差风险研究的敏感性分析显示,类似的聚合死亡风险为0.25 (95%CI:0.21,0.29).
结论:
- 大约四分之一的流感患者被送往重症监护室,死于这种疾病.
- 这些发现强调了强有力的疫苗接种计划和针对严重流感的优化治疗策略的迫切需要.
- 需要对危险因素和干预措施进行进一步的研究,以改善重症流感患者的治疗结果.
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