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IL-8作为衰老与老年人流感抗体反应受损之间的因果关系

Huy Quang Quach¹, Krista M Goergen², Diane E Grill²

¹Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.

The Journal of infectious diseases

|March 17, 2025

概括

干白素-8 (IL-8) 在中介抗体对老年人流感疫苗的反应中起着关键作用. 抑制IL-8可能会提高疫苗在这个人群中的有效性.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
老年学是一门学科.

背景情况:

已知老年人对MF59辅助 (MF59Flu) 和高剂量 (HDFlu) 流感疫苗的抗体反应.
对老年人这些疫苗的细胞免疫反应数据有限.

研究的目的:

调查老年人接种流感疫苗后的细胞免疫反应,特别是细胞因子和化学因子概况.
为了确定特定的细胞因子/化学因子和对MF59F和HDF疫苗的抗体反应之间的关联.

主要方法:

在四个时间点 (接种疫苗前和接种疫苗后的1,8,28天) 从106名MF59F和112名HDF接种者收集了血液样本.
抗体标位是使用凝血抑制试验测量的.
从PBMC中使用多重测定量定了八种促炎细胞因子/化学因子 (IFN-α2a,IFN-γ,IP-10,MCP-1,MIP-1α,IL-1β,IL-6,IL-8).

主要成果:

第1天的IL-8 (IL-8) 水平和从第0天到第1天的IL-8的变化与年龄呈正相关性.
1日增加的IL-8水平与28日抗体标位有负相关性.
因果调解分析显示,在第8天和第28天,IL-8显著调解了抗体反应.

结论:

介质素-8 (IL-8) 被认为是对老年人流感疫苗接种抗体反应的重要调解剂.
抑制IL-8是一种潜在的分子干预策略,可以增强老年人疫苗诱导的抗体反应.

关键词:

在 HDFlu 上播放.接种流感疫苗可以预防流感.MF59 流动的情况抗体是一种抗体.化学物质 (chemokines) 是一种化学物质.细胞因子细胞因子年龄较大的成年人.

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