[维生素D - 目前的建议是什么?]
1Forschungszentrum Alter und Mobilität, Universität Zürich.
Therapeutische Umschau. Revue therapeutique
|March 17, 2025
概括
每日补充维生素D可以减少老年人缺乏维生素D的骨折和跌倒风险. 然而,在没有缺陷的健康个体中,高剂量或补充剂没有任何好处,可能会增加风险.
科学领域:
- 营养科学 营养科学
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 维生素D补充研究已经发展,对其有效性和风险有了新的见解.
- 之前的研究表明,每天800 IU维生素D对缺陷老年人骨折和跌倒预防有好处.
- 高剂量或间歇性维生素D对骨折和跌倒的预防是无效的,可能有害的.
研究的目的:
- 审查有关维生素D补充剂对骨健康和更广泛的健康结果的现有证据.
- 根据剂量,补充方案和个人健康状况来区分维生素D的作用.
- 突出最近关于维生素D对免疫系统和癌症风险的影响的发现.
主要方法:
- 分析高质量的研究,包括大型随机对照试验,涉及超过36000名参与者.
- 评估每日与间歇性高剂量维生素D补充剂的策略.
- 对最近的试验 (VITAL,DO-HEALTH) 的综述,这些试验在健康人群中每天检查2000 IU的维生素D.
主要成果:
- 每天800 IU的维生素D可以减少缺陷和现有跌倒风险的老年人骨折和跌倒风险.
- 维生素D补充剂在没有缺乏或骨质疏松症的健康个体中没有显示任何额外的保护.
- 在健康的老年人中,每天2000 IU的维生素D对免疫系统有好处,减少晚期癌症,癌症死亡率和自身免疫性疾病.
结论:
- 最佳的维生素D补充策略取决于个人的缺乏状态和健康目标.
- 每日低剂量维生素D对于特定人群是有效的,而高剂量或间歇性疗法不建议用于骨折预防.
- 新出现的证据表明,每日维生素D对免疫功能和健康个体的癌症风险降低有潜在的益处.
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