长期发烧在一个耐多药性伤寒患者尽管适当的抗菌疗法:一个案例报告
Abdulrahiman Cheenammdath House1, Rikaz Bizzari1, Moza Alhammadi2
1Department of Pediatrics, Hatta Hospital, Dubai Health, Dubai, ARE.
Cureus
|March 17, 2025
概括
抗药多种类型的伤寒热 (MDR S. 甲状腺炎 (Typhi) 需要仔细选择抗生素. 这一案例表明,美罗和阿兹菌素有效地治疗了耐药菌株,突出了需要警监测和治疗调整的必要性.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 全球健康 全球健康
背景情况:
- 伤寒发烧,由沙门氏菌 (Salmonella enterica) 血清型 Typhi (S. 伤寒 (Typhi) 是一个主要的全球健康问题.
- 多抗药性 (MDR) 和广泛抗药性 (XDR) 病例的增加 伤寒菌株使治疗选择变得复杂.
研究的目的:
- 报告一个MDRS.病例. 小儿病患者的伤寒感染.
- 为了说明治疗耐药型伤寒的挑战以及适当的抗生素治疗方案的重要性.
主要方法:
- 一个案例研究10岁的男孩长期发烧疾病后旅行到一个流行地区.
- 首次使用塞夫特里亚克松治疗无效;转换为梅罗和阿齐思罗米辛.
- 监测临床和实验室参数以评估治疗反应.
主要成果:
- 这位患者患有扩展谱β-乳糖酶 (ESBL) 产生的S. 抗 ceftriaxone 的 Typhi 菌株. 这种菌株对 ceftriaxone 具有抗性.
- 临床改善在第五天被观察到,发烧在第11天消失.
- 炎症标志物有所改善,细菌病消失,12日通过血液培养得到证实.
结论:
- 在MDR和XDRS. 甲状腺炎带来了重大的临床和公共卫生挑战,国际旅行加剧了这一问题.
- 有效的管理需要警的耐药性监测,适当的抗生素管理,并遵守基于证据的指导方针.
- 及时调整抗生素治疗方案对于耐药型伤寒热的成功治疗结果至关重要.
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