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化疗相关心脏毒性:一个沉默的威胁,在回顾性队列研究中得到证实
Felipe A Muñoz-Rossi1,2, Santiago Cárdenas-Corredor3, Luis Fernando Saldarriaga Osuna3
1Internal Medicine, Universidad Nacional de Colombia, Bogotá, COL.
Cureus
|March 17, 2025
概括
癌症治疗可能会导致心脏损伤 (心脏毒性). 使用心声回声和生物标志物的早期检测对于管理癌症患者和改善他们的生活质量至关重要.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 临床研究 临床研究
背景情况:
- 癌症是全球和哥伦比亚的主要死亡原因.
- 抗瘤治疗可以导致心脏毒性,在化疗期间或之后表现出来.
- 早期识别有风险的患者对于预防严重的心脏并发症至关重要.
研究的目的:
- 调查正在接受治疗的癌症患者心脏毒性的发生率和危险因素.
- 评估用于早期检测心脏毒性的诊断工具的实用性.
主要方法:
- 进行了一项描述性的观察性队列研究.
- 包括197名18岁以上的患有活跃癌症 (血液或非血液) 的患者.
- 从2016年至2019年期间在哥伦比亚大学医院接受治疗的患者收集的数据.
主要成果:
- 20名患者 (10%) 发生心脏毒性.
- 脱脂症 (45%) 和动脉高血压 (28.7%) 是常见的并发症.
- 环素暴露增加了心脏毒性风险 (RR=2.074);受影响患者的左心室喷射率较低.
结论:
- 心声和生物标志物是早期心脏毒性识别的关键策略.
- 将这些工具集成到护理算法中可以减少心脏毒性发生率.
- 早期检测和监测可以改善瘤患者的管理和生活质量.
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