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Igori Balta¹, Joanne Lemon², Anna Gadaj³

¹Faculty of Bioengineering of Animal Resources, University of Life Sciences King Mihai I from Timisoara, Timisoara, Romania.

Frontiers in microbiology

|March 17, 2025

概括

重金属和微塑料通过促进微生物生态系统中的基因转移,作为抗菌素耐药性 (AMR) 的关键驱动因素. 解决这些污染物对于缓解耐药性决定因素的传播至关重要.

科学领域:

环境科学环境科学
微生物学微生物学
公共卫生公共卫生

背景情况:

由于重金属 (HM) 和微塑料 (MP) 造成的环境污染越来越令人担忧.
这些污染物越来越多地与抗菌素耐药性 (AMR) 的全球挑战有关.
从历史上看,HM已经影响了微生物的进化,早于抗生素耐药性基因 (ARG).

研究的目的:

探索微生物生态系统中连接HM,MP和AMR的复杂机制.
阐明由环境污染物驱动的共同选择和交叉抵抗机制.
突出卫生医生和议员作为AMR驱动者的协同作用.

主要方法:

对有关HM-MP-AMR相互作用的现有文献的审查.
共同选择和交叉抵抗机制的分析.
研究生物膜和有机物质在基因转移中的作用.

主要成果:

通过流量系统和遗传共同调节,HM (例如,Pb,Hg,As) 持续选择耐药性特征.
病原生物膜的基质是MP,它加速了ARG和重金属抗性基因 (MRG) 的水平基因转移 (HGT).
有机物调节HM的生物可用性,并影响ARG的丰度.

结论:

保健医生和国会议员协同推动AMR,创建基因交换热点.
土壤和水生态系统作为ARG和ARG-MRG组合的水库.
迫切需要综合的环境和公共卫生战略 (一种健康方法),以减轻污染物驱动的AMR.

关键词:

抗微生物耐药性抗微生物耐药性细菌细菌细菌是一种细菌.环境污染环境污染环境污染重金属重金属的使用.微塑料微塑料的使用

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